All Betfred Championship sides, barring Toulouse Olympique, entered the Coral Challenge Cup at the Fourth Round stage as the British Army and community side Underbank Rangers enter unknown territory.
With a handful of postponed games due to Storm Ciara, 28 names go into the hat, with only space for 24 teams in the next round.
One of the stand out fixtures from the draw is Sheffield Eagles vs Halifax which is a repeat of the Championship Season Opener in which Halifax come out on top 18-17.
The British Army will face either Rochdale Hornets or York Acorn, as they wait for that tie to be played next weekend.
Huddersfield-based community side, Underbank Rangers travel the short distance to face Bradford Bulls in another West Yorkshire Derby.
In an all-Championship clash, York City Knights travel to the capital as they play London Broncos at Ealing. Fellow London club, Skolars, will need to overcome Barrow Raiders in their rearranged tie if they wish to face Featherstone Rovers just a week later.
All ties are due to take place on the weekend of February 22nd/23rd.
The full draw is as follows: