It was Craig Bellamy versus Adam O'Brien as the Melbourne Storm welcomed the Newcastle Knights to the Sunshine Coast Stadium, with the visitors looking to move up to sixth on the ladder.
Parramatta Eels travelled the ANZ Stadium to face the Giant-killing Canterbury Bulldogs as these two Western Sydney rivals went head-to-head in round 12.
Manly Sea Eagles welcomed the Penrith Panthers to Lottoland, with the home side looking to break into the top eight, come the end of round 12, and the visitors hoping to extend their lead at the top.
The Canberra Raiders travelled to Townsville on the verge of the top four as they looked to overcome the North Queensland Cowboys for their third win on the bounce.
Despite plenty of injuries, the Sydney Roosters still fielded an extremely strong side as they welcomed a Gold Coast Titans side still looking for consistency in their performances.
The Brisbane Broncos faced a tough task turning around their nightmare season against an in-form Cronulla Sharks side looking to get into the top four conversation, after five wins from their last six.
The New Zealand Warriors faced the Wests Tigers at the Sydney Cricket Ground as both sides looked to work themselves into the top-eight come the end of the season.
St George Illawarra and South Sydney battled as top eight outsiders after round 11 defeats delivered significant setbacks to their 2020 finals hopes.